Obesity and diabetes linked to dementia

June 23, 2013

A review of the world's scientific literature shows that high-sugar diets
can lead to loss of mental function that increases risk for Alzheimer's
disease and other forms of dementia (Curr Opin Clin Nutr Metab Care,
July, 2013;16(4):440-5). High sugar diets are a major risk factor for
diabetes, which in turn is a risk factor for Alzheimer's disease (Chem
Soc Trans, 2005 Nov;33(Pt 5):1041-4).

High-sugar diets prevent your cells from responding to insulin. This is
called insulin resistance, which leads to obesity and diabetes. Insulin
resistance may also cause Alzheimer's disease (CNS Drugs,
2003;17(1):27-45). Your brain requires both sugar and insulin to function
properly. Many recent studies show that insulin is necessary for memory.
Brain cells are loaded with insulin receptors, specifically in the medial
temporal regions of the brain that are the source of memory. Insulin also
regulates the amyloid precursor protein and its derivative beta-amyloid
(abeta), that cause the senile plaques, that are diagnostic of
Alzheimer's disease. Insulin prevents the breakdown of abeta in Alzheimer
plaques (Drugs Today, 2006 Jul;42(7):481-9).

Prevention of Dementia
Accumulating evidence show that everything that treats diabetes and
insulin resistance may also help to prevent Alzheimer's disease.
Therefore, prevention of dementia should include lifestyle factors to
prevent weight gain and diabetes:
eat less,
exercise more,
avoid sugar-added drinks and foods except during intense exercise,
restrict red meat (blocks insulin receptors) and fried foods,
eat more fruits and vegetables, and
get blood levels of hydroxy vitamin D above 76 nmol/L.

Dr. Gabe Mirkin's Fitness and Health e-Zine